The Role of Irisin in Gestational Diabetes Mellitus: A Review
نویسندگان
چکیده
Irisin is a newly described myokine that improves insulin resistance via the browning of white adipose tissue. Irisin appears to be secreted in response to exercise, providing a hormonal link between exercise and improved insulin sensitivity. Irisin expression has been demonstrated to increase after acute exercise and cold exposure in animal and human studies. Circulating irisin is decreased in metabolic disease states characterised by insulin resistance, such as type 2 diabetes mellitus, non-alcoholic fatty liver disease, chronic kidney disease and metabolic syndrome. The role of irisin in in normal pregnancy as well as gestational diabetes mellitus is yet to be fully elucidated. To date, there are inconsistent reports regarding the changes in circulating irisin that occur in pregnancy and Gestational Diabetes Mellitus (GDM). Overall, it appears that irisin levels increase with pregnancy, and that the placenta expresses low levels of irisin. There is evidence that irisin levels are decreased in GDM pregnancy. With further research, irisin may prove a future therapeutic target or risk marker for GDM as well as other disease states characterised by insulin resistance.
منابع مشابه
معرفی هورمون ورزش (Irisin)
Introduction: Almost 15% of world populations suffer from obesity. Obesity and insulin resistance are the key pathogenesis risk factors of type 2 diabetes mellitus (T2DM) and cardiovascular disease. Exercise training can accelerate metabolism and help to prevent the obesity and diabetes through induction of Irisin and triggers conversion of white adipose tissue to brown adipose tissue. Metho...
متن کاملThe Role of Probiotics on Controlling Diabetes Mellitus: An Umbrella Review
Background and purpose: There are some evidences about the effects of probiotics on controlling different types of diabetes and reviewing these studies could be of great help in clarifying the efficacy of these dietary supplements in management of diabetes. Thus, we aimed to review the role of probiotics on glycemic control and other biochemical parameters in patients with diabetes. Materials...
متن کاملFirst Trimester Potential Biochemical Predictive Tests for Gestational Diabetes Mellitus: A Systematic Review
Objective: Gestational diabetes mellitus (GDM) is the most common metabolic complication during pregnancy. So, a large number of studies have evaluated the usefulness of different screening tests. The aim of this study was focused on the potential of only first-trimester screening used in the prediction of GDM. Materials and Methods: In this systematic review, we searched PubMed, EMBASE, and S...
متن کاملP-167: Association between Pregnancy Dietary Iron Intake and Gestational Diabetes Mellitus
Background: Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications affecting approximately 7% of all pregnancies and up to 14% of pregnancies in high-risk populations. Although, dietary iron intake is one of preventive factors for Iron deficiency which leads to less preterm delivery, prematurity, and SGA but iron is a strong pro-oxidant and high body iron levels c...
متن کامل